Of the 17 AAG. The oxidative Fesoterodine Toviaz metabolism of 17 wide on each AAG No page allylamino 17 in consequence of the formation of GA 17 and the epoxide and diol metabolites. The hydroxylation of C22 and demethylation of the methoxy groups were as minor biotransformation of 17 AAG in HLM detected. In contrast, the C23-hydroxylation and demethylation of the methoxy groups of the prime Re biotransformation of 17 DMAG in HLM. AAG Similar to 17, the hydroxylation of the carbon atom adjacent to the nitrogen atom produces an intermediate layer carbinolamine stable. Subsequently End has suffered the loss of H2O and M2 formed an imine metabolite. In general, carbinolamines as unstable intermediates in the demethylation N. The most famous carbinolamines tend imine intermediate form by loss of water or decompose in amine dealkylation by loss of the aldehyde or ketone. However carbinolamines stable imines and exist in w Ssrigen L Solutions under certain circumstances Ends. For example, carbinolamines and imines are stabilized by adjacent electron-withdrawing groups. Zus Tzlich can hydroxymethylpentamethylmelamine a stable carbinolamine was identified as a metabolite in the plasma of M Mice and rat liver microsomes, since the neighboring substituents delocalize the unpaired electrons of nitrogen and stabilization of the carbinolamine pairs. In addition, stable carbinolamines isolated or detected as a metabolite in a number of drugs, including normal benzamides, carbamates, procarbazine, N methylcarbazole, medazepam, verapamil, and pyridopyrazines pyrimidinyl ecabapide. Is a quinone electron withdrawing group known resonance. The presence of quinone addition to the nitrogen in M2, M5 and M6 erm glicht Of 17 DMAG stabilizes the delocalization of the lone pairs of nitrogen and metabolites. 17 AAG is a known substrate of CYP3A4. In the current study, experiments of the reaction Ph Notypisierung using recombinant human P450 and P450-selective inhibitors of chemicals that inhibit CYP3A4 and CYP3A5, the major cytochrome P450 oxidative metabolism of 17 DMAG in HLM are.
In addition, CYP2C8, valuable tool for treatment monitoring at the molecular level. In molecular imaging is still not available, such as routine clinical modality t, however, optical Ger-run breast imaging with diffuse near-infrared light are currently being evaluated in clinical trials. The breast is a target organ Rapamycin for diffuse optical imaging, the light can penetrate as deep into the tissue enough to go without by other highly absorbent or scattering tissue. Optical imaging is widely used in the pr Clinical and novel molecular imaging used primarily targeting molecules cancerassociated grow quickly. The main advantages of optical imaging is that it uses no ionizing radiation and optical imaging probes are much less Co Cheaper and easier to produce than PET tracers. However, the quantification of the optical signal is difficult and complex than the PET imaging. We have a pr Clinical model, established to investigate the feasibility of optical imaging as a tool for molecular imaging for monitoring treatment. If the quantification of the signal is sufficiently precise to measure the effects of the treatment is known, k Optical imaging can play a putative drug targets The key.