Acknowledgements and Funding This work was financially supported

Acknowledgements and Funding This work was financially supported by Shandong JQ-EZ-05 Medical Research Council Grant. References 1. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA: Creation of human tumour cells with defined genetic elements. Nature 1999, 400:464–68.PubMedCrossRef 2. González-Suárez E, Samper E, Ramírez A, Flores JM, Martín-Caballero J, Jorcano JL, Blasco MA: Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J 2001, 20:2619–30.PubMedCrossRef 3. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich

SL, Shay JW: Specific association of human telomerase activity with immortal cells and cancer. Science 1994,266(5193):2011–5.PubMedCrossRef 4. Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, et al.: The RNA component of human telomerase. Science 1995, 269:1236–41.PubMedCrossRef

5. Mitchell GSK1210151A ic50 JR, Wood E, Collins K: A telomerase component is defective in the human disease dyskeratosis congenita. Nature 1999,402(6761):551–5.PubMedCrossRef 6. Yeo M, Rha SY, Jeung HC, Hu SX, Yang SH, Kim YS, An SW, Chung HC: Attenuation of telomerase activity by hammerhead ribozyme targeting human telomerase RNA induces growth retardation and apoptosis in human breast tumor cells. Int J PND-1186 concentration cancer 2005,114(3):484–9.PubMedCrossRef 7. Nosrati M, Li S, Bagheri S, Ginzinger D, Blackburn EH, Debs RJ, Kashani-Sabet M: Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA. Clin Cancer

Res 2004,10(15):4983–90.PubMedCrossRef 8. Theimer CA, Blois CA, Feigon J: Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function. Mol Cell 2005,17(5):671–82.PubMedCrossRef 9. Jeong S, Sefcikova J, Tinsley RA, Rueda D, Walter NG: Trans-acting hepatitis delta virus ribozyme: catalytic core and global structure are dependent on the 5′ substrate sequence. Biochemistry 2003,42(25):7727–40.PubMedCrossRef 10. Roy GA, Perealt JP: Delta ribozyme has the ability to cleave in trans mRNA. Nucleic Acids Res 1999,27(4):924–48.CrossRef 11. Gondert ME, Tinsley Ribonucleotide reductase RA, Rueda D, Walter NG: Catalytic core structure of the trans-acting HDV ribozyme is subtly influenced by sequence variation outside the core. Biochemistry 2006,45(24):7563–73.PubMedCrossRef 12. Nishikawa F, Roy M, Fauzi H, Nishikawa S: Detailed analysis of stem I and its 5′ and 3′ neighbor regions in the trans-acting HDV ribozyme. Nucleic Acids Res 1999,27(2):403–10.PubMedCrossRef 13. Jeong S, Sefcikova J, Tinsley RA, Rueda D, Walter NG: Trans-acting hepatitis delta virus ribozyme: catalytic core and global structure are dependent on the 5′ substrate sequence. Biochemistry 2003,42(25):7727–40.PubMedCrossRef 14. Fauzi H, Kawakami J, Nishikawa F, et al.

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