There were no group differences in demographic characteristics, except for the cognitive score. Our finding of a higher cognitive score at 2002 and 2005 in the E4- group is consistent with previous studies.15 Table I Demographic characteristics in the

analysis of the effect of lipids/lipoproteins. a P value was calculated by unpaired two-tailed t test. b P value was calculated by Pearson χ2 two-tailed test. c P value was calculated by analysis of covariance … Figure 1 and 2 show the median plasma concentrations of lipids for the three always find useful information strata according to the tertiles of plasma levels of lipids/apoE, and the mean cognitive scores of the E4- and E4+ groups at 2002 and 2005 according Inhibitors,research,lifescience,medical to the three strata of plasma concentrations of lipids/apoE. Figure 1. Mean cognitive test score of each tertile groups of lipid levels in ApoE4+ group. a, data Inhibitors,research,lifescience,medical are mean after adjustment for age, sex, years of education, Geriatric Depression Scale score, cigarette smoking, and medical history of cardiovascular disease, diabetes … ANCOVA analysis evaluating the influence of lipids level on cognitive function

showed a mean significant Inhibitors,research,lifescience,medical influence of the HDL level on composite cognitive scores at both 2002 and 2005 in the E4- group (F2,498=9.3, P<0.001 for 2002, F2,498=9.3, P<0.001 for 2005). Subjects with higher HDL concentrations had higher cognitive scores. The effect Inhibitors,research,lifescience,medical size of the influence of the plasma HDL level on cognitive score was more than 0.01(η2=0.04 for 2002, η2=0.04 for 2005). No such significant association was observed in the E4+ group (Figure 2). Figure 2. Mean cognitive test score of each tertile groups of lipid levels in the ApoE4- group. a, data are mean after adjustment for age, Inhibitors,research,lifescience,medical sex, years of education; Geriatric Depression Scale score, cigarette smoking, and medical history of cardiovascular disease, ... A significant main effect of the apoE level was found by ANCOVA on composite cognitive scores at 2002 and 2005 in both of the E4- and E4+ group (F2,498=11.3, P<0.001 for 2002, F2,498=7.3, P=0.001 for 2005

in the E4-, and F2,102=7.0, P=0.001 for 2002, F2,102=4.0, Batimastat P=0.02 for 2005 in the E4+ ). Subjects with higher plasma apoE concentration had higher cognitive scores in both groups. The effect size of the association of the plasma apoE level on these cognitive scores was more than 0.01(η2=0.04 for 2002, η2=0.03 for 2005 in the E4-,and η2=0.12 for 2002, η2=0.07 for 2005 in the E4+). Why are cognitive scores associated with plasma apoE and HDL levels? Each of the analyses using the data from the baseline and 3-year follow-up examinations revealed that cognitive scores were associated with the plasma apoE level in both E4- and E4+, and the HDL level in E4-. We will discuss these findings. ApoE plays a significant role in response to neuronal injury by reducing inflammation, endothelial dysfunction, and lipid oxidation.