The tree was constructed using the partition modeling feature included in the JMP 7 software package. The software was allowed to determine the best next cut, and additional cuts were not made to a branch with a sample size animal study less than 30. Finally, guided by the rule of 10, the ��best�� 3 variables were determined from the first 3 cuts in the tree model and included in a final multivariate Cox Proportional Hazards model of survival for the 6 months following ICU admission. In additional exploratory studies, the study cohort was further divided and analyzed in three Inhibitors,Modulators,Libraries subgroups: the HSCT Admission group consisted of patients who were admitted to the ICU during the course of their initial hospitalization for hematopoietic transplant (n = 70), the Early Readmission group was patients who were discharged from the hospital status post-HSCT but who require ICU admission within 100 days of their transplant (n = 33), and the Late Readmission group was HSCT patients who required ICU admission more than 100 days after their transplant (n = 51).
Six-month survival rates were compared among the three groups. 3. Results 3.1. HSCT and ICU Admission UCLA performed 605 adult HSCT transplants (400 autologous, 205 allogeneic) during this study period. Three patients admitted to the ICU for monitoring after elective surgeries were excluded from Inhibitors,Modulators,Libraries Inhibitors,Modulators,Libraries our study. After Inhibitors,Modulators,Libraries the exclusion of these patients, 154 patients, or 25% of the total adult HSCT cohort, required 179 ICU admissions. Admission to the ICU was more common after allogeneic transplant (46%) than autologous transplant (15%).
During the initial hospitalization for HSCT, 70 patients (11.6% of the total cohort) required admission to the ICU. Similarly, during the initial hospitalization for HSCT, ICU admission was more common after allogeneic transplant (22.4%) than autologous Inhibitors,Modulators,Libraries transplant (6%). 3.2. HSCT Patient Characteristics The characteristics of these 154 HSCT patients admitted to the ICU are summarized in Table 1. There were 91 males and 63 females. Overall, the top three underlying diseases that necessitated HSCT were acute myeloid leukemia (29%), non-Hodgkin’s lymphoma (21%), and acute lymphoblastic leukemia (16%). The average age was 44 (range was 18�C77), and the median length of ICU stay was 5 days (IQR 2, 11). Sixty-five patients (68%) had signs of GVHD, and 66 patients (43%) were neutropenic at one point during their ICU admission.
Mechanical ventilation was required in 110 patients (71%), vasopressor-use was required in 104 patients (66%), and dialysis was required in 63 patients (41%). The majority of patients who needed mechanical ventilation or vasopressors during their ICU admission required initiation of these AV-951 interventions on their first ICU day, while initiation of HD generally occurred during the first week or not at all (Figure 1).