The patient is a sporadic case of VHL disease, with a de novo nonsense mutation in codon Selleck Quizartinib 161 with C -> T transition at nucleotide position 694 of the VHL gene. Multiple RCHs were noted in both eyes. Four small RCHs were found in the left eye and were treated with laser photocoagulation. Three large RCHs in the peripheral retina of the right eye were complicated with cystoid macular edema and subretinal fluid accumulation. The RCHs were treated with PDT combined with IVB, and bullous exudative RD developed on the second day after treatment.
Three months after PDT, the tumors had regressed significantly, but exudative RD persisted, despite multiple IVB and intravitreal triamcinolone acetonide injection (IVTA). External drainage with sclera buckling, IVB, and IVTA were performed, and the retina attached after surgical
intervention. The application of PDT in the treatment of RCHs and its possible complications are discussed. Copyright (C) 2013 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.”
“Background: Cardiac troponin T elevation after coronary intervention has been demonstrated Epoxomicin purchase to be associated with the prognosis of coronary artery disease (CAD). However, there were few studies about comprehensive risk factors analysis of troponin T elevation after elective drug-eluting stent (DES) implantation.
Hypothesis: The prognosis of CAD after coronary interventions was associated
with clinical and procedural risk factors of CAD, such as age, hypertension, severity extent of CAD and so on.
Methods: From March to December in 2010, patients Fosbretabulin cost with stable CAD were admitted for elective coronary intervention in our hospital. They were divided into an elevated troponin T group and a normal troponin T group by postprocedural troponin T. Clinical factors, laboratory-test factors, and angiographic factors (such as gender, age, cholesterol, Gensini score, and others) were analyzed.
Results: A total of 209 patients with an average age of 64.0 +/- 9.9 years were enrolled in the study: 70 patients with elevated troponin T (= 0.03 ng/mL) after DES implantation and 139 patients with normal troponin T (< 0.03 ng/mL). After univariate analysis, we found that age, hypertension, total cholesterol, low density lipoprotein-cholesterol (LDL-C), Gensini score, number of stenosed vessels, and total implanted stents were associated with postprocedural troponin T elevation. According to the results of multivariate analysis, we found that age, total cholesterol, number of stenosed vessels, and number of implanted stents were independent risk factors of postprocedural troponin T elevation.
Conclusions: Age, serum total cholesterol, number of stenosed vessels, and number of implanted stents could be independent risk factors of troponin T elevation after elective DES implantation.