697 1.016 2.766 4.221 1.013 2.978 6 5.204 0.928 2.130 5.719 PF-04217903 0.887 1.489 12 6.331 1.047 1.702 6.417 0.918 1.270 24 5.813 1.439 2.550 6.07 1.030 1.277 H. influenzae 2 2.703 1.670 3.585 3.864 1.688 4.542 4 4.227 1.424 2.766 4.841 1.160 2.128 6 5.217 1.216 1.915 5.669 0.974 1.489 12 6.610 1.163 1.479 6.724 0.891 1.277 24 6.023 1.484 1.915 6.048 1.042 1.277 M. catarrhalis 2 2.727 1.634 5.404 4.002 1.427 3.970 4 4.163 1.968 4.542 4.590 1.298 3.404 6 4.652 1.762 3.192 4.898 1.169 1.915 12 5.956 1.792 2.340 6.068 0.884 1.277 24 6.530 1.960 2.553 6.004 0.846 1.277 VOL. 48, 2004 out action ABT tion is 492 to 207 inhibited the growth of respiratory pathogens and the reduction of the colony begins to emerge. By studying the FA What we change EC50 and EC90 compared to the other concentrationresponse the curve at any moment.
If the distance between the EC50 and EC90 shrinks over time, the model is a function of concentration. In our model, the EC50 remained relatively constant, w decreased During the EC90 to 24 h, the distance between EC50 and EC90 narrowed. For this reason, ben h Here concentrations BMS-387032 of antibiotics CONFIRMS, to achieve 90% of the maximum activity T at earlier. Can represent the slight increase in the EC50 and EC90s observed by two quinolones at 24 h, a small amount of regrowth seen at bacteriostatic concentrations. Although full-January-February log10 increase in the number of colonies are shown in Fig shops protected. 1 can suffice a slight increase in the number of colonies in several bacteriostatic concentrations to affect the EC50 and EC90.
In comparison to the value at 12 h, there was a decrease in Emax at 24 h, which is a combination of a slight regrowth, the Clock at 24 in a row and a slight reduction in the number of colonies for the contr The bacterial isolates and at lower concentrations to achieve maximum growth rate than bacteria. When comparing the activity t of ABT 492 to that of levofloxacin, we may use the visit to the M RIGHTS compare EC50. The connection with the gr Th power is the lowest EC50. We k Can seen from Table 2, which has the standard errors of inclusion, see a lower EC 50 tested levofloxacin against all species between 6 and 24 h after exposure to antibiotics. In Similar way, levofloxacin has a lower calculated EC90. For this study, antibacterial concentrations in multiples of the MIC was measured.
We calculate to make our data as such, the results of the sigmoidal models Comparables for ABT 492 and levofloxacin, because the MIC was very different. Although levofloxacin May Abs M Chtiger be a ratio Ratio to its EC50, EC50, if we are to be multiplied by the MIC, levofloxacin has a much h Here EC 50 with respect to the concentration of antibacterial that ABT-492. Which are used in this study further in order to optimize future dosages for these agents. ABT 492 showed a konzentrationsabh Independent activity t in these models, however the future in vitro and in vivo studies with this agent dynamic modeling are needed to further validate the pharmacodynamics. Pharmacodynamic Modeling of other quinolones such as levofloxacin, a better correlation with the liquid Surface under the concentration-time curve over 24 h, based on the MIC of the bacteria. Independent ngig of whether the antibiotic pharmacodynamics correlate better with the concentration or dependence Dependence of the AUC to MIC-money ratio, it is increasingly important to the free concentrations of the antibiotic in serum concentrations of the antibiotic or the maximization