“
“Objective: One in three cancer patients

will experience significant psychosocial distress, yet less than 10% will seek formal counseling. Who are the patients accessing counseling and what are their presenting needs? The purpose of this study was to identify referral patterns and psychosocial distress in cancer patients newly referred to a psycho-oncology counseling service.

Methods: Consecutive new referrals were tracked over 1 year Selleckchem URMC-099 (n=361). On initial visit, 145 patients completed a demographic survey, Brief Symptom Inventory-18 (BSI-18), Cancer Coping Questionnaire and Medical Outcomes Study Social Support Survey.

Results: Approximately one in five newly referred patients never attended counseling, with a significant representation of men (p=0.016) and lung cancer patients (p=0.010). Of 361 referrals, 295 patients attended initial counseling, 259 were approached, and 145/259 (56%) completed the survey. Most were women (79%), urban-dwelling (73%), diagnosed Epacadostat purchase with non-advanced cancer (72%), well-educated (68%) and married (56%); average age of 52 years (SD=12.3). Two most common diagnoses were breast (36%) and genitourinary (14%) cancers. A total of 59% were significantly distressed (BSI-18 global severity index T-score >= 63) with less available social support than non-distressed patients (p=0.022). Coping strategy use did not differ significantly between distressed

and non-distressed groups. Two of five patients were not significantly distressed.

Conclusions: Most cancer patients attending counseling are well-educated urban residing women, with significant psychosocial distress. Further research

is needed to better understand barriers and appropriate screening methods for accessing counseling, as well as the needs of men, advanced cancer patients, rural residents, and less well-educated people. Copyright (C) 2010 John Wiley & Sons, Ltd.”
“Background. 5 alpha-Reductase deficiency (5RD) is an uncommon autosomal recessive disorder of sexual differentiation. Pevonedistat It results from impaired conversion of testosterone to dihydrotestosterone due to mutations in the steroid 5 alpha-reductase type 2 gene (SRD5A2). Mutations in SRD5A2 have not been previously reported in Indian patients with 5RD.

Aim: To delineate the clinical features and mutations in the SRD5A2 gene in Indian patients with 5RD.

Patients and Methods: The SRD5A2 gene was sequenced in two unrelated patients with elevated testosterone/dihydrotestosterone ratio and in one patient with classical clinical features and virilization at puberty (in whom the ratio could not be measured due to prior gonadectomy). The prevalence of SRD5A2 mutations was also studied in 52 healthy ethnic control subjects by PCR-RFLP.

Results: Two patients, both from the north Indian state of Uttar Pradesh, carried the homozygous missense mutation p.