Galli M, Cicalese A, S NVP-LAQ824 LAQ824 Piccinin, P Gasparini, Luise C, C Schurra, Garre M, Nuciforo PG, Bensimon A, Maestro R, Pelicci PG, d �A DDA di Fagagna F. Oncogene-induced senescence is a response to DNA-Sch To that triggered by DNA hyper-replication St. Nature 2006, 444:638 42 . 13th Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Butel JS, Bradley A. p53-deficient Mice are a normal development, but anf Llig for spontaneous tumors. Nature 1992; 21 356:215. 14th Dornan D, Shimizu H, Mah A, T Dudhela, Eby M, O ourke K, Seshagiri S, Dixit VM. ATM is involved autodegradation the E3 ubiquitin ligase COP1 after DNA-Sch To. Science 2006, 126 313:1122 . 15th Giaccia AJ, Kastan MB. T the complexity of p53 modulation: emerging trends from the different signals.
Genes & Dev BMS-599626 1998; 12:2973 983rd 16th VG Gorgoulis, LV Vassiliou, Karakaidos P, Zacharatos P, A Kotsinas Liloglou T, M Venere, Ditullio RA Jr, Kastrinakis NG, Levy B, D Kletsas, Yoneta A, Herlyn M, Kittas C, Halazonetis TD. The activation of the control point The DNA-Sch Genomic instability and the t in human pr Kanzer Sen sions L. Nature 2005; 13th 434:907 17th Gurley KE, Kemp CJ. ATM is irradiated required for the induction of apoptosis in p53 and epithelial tissue. Mol Cancer Res 2007; 5:1312 318 . 18th Hainaut P, M. Hollstein p53 and human cancer: the first ten thousand mutations. Adv Cancer Res 2000; 77:81 37. 19th Harvey M, McArthur MJ, Montgomery CA Jr, Butel JS, Bradley A, Donehower LA. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice M. Nature Genet 1993; 5:225 29.
20th Herzog KH, Chong MJ, Kapsetaki M, Morgan JI, McKinnon PJ. Requirement for the ATM to cell death caused by ionizing radiation in the developing central nervous system induced. Science 1998; 280:1089 091st 21st Ichijima Y, R Sakasai, Okita N, Asahina K, Mizutani S, Teraoka H. The phosphorylation of histone H2AX at M phase in human cells, without response to DNA-Sch The. Biochem Biophys Res Commun 2005; 336:807 12. 22nd Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA. Analysis of the spectrum of tumors in p53 mutant mice M. Curr Biol 1994; 04:01 . 23rd Jonkers J, Meuwissen R, van der GH, Peterse H, van dv, Berns A. Synergistic tumor suppressor activity T of BRCA2, p53 in a conditional mouse model of breast cancer. Nature Genet 2001; 29:418 25th 24th Kelly-Spratt KS, Gurley KE, Yasui Y, Kemp CJ.
p19Arf suppresses growth, progression and metastasis of carcinomas ERS-driven by p53-dependent Independent signaling pathways and regardless. PLoS Biology 2004, 2: E242. 25th Kemp CJ. Skin cancer in M Nozzles in several steps as a model to investigate the F Ability of cancer cells. Sem Cancer Biol 2005; 15:460 73 . Bailey et al. Page 8 Mol Cancer Res author manuscript in PMC 2009 1 July. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript 26th Kemp CJ, Donehower LA, Bradley A, Balmain A. Reduction of p53 gene dosage is not increased Ht initiation or F Promotion but enhances malignant progression of chemically induced skin tumors. Cell 1993; 74:813 22. 27th Kemp CJ, Wheldon T, M deficient Balmain A.
p53 mice are extremely anf For radiation-induced tumorigenesis llig. Nature Genet 1994; 8:66 9. 28th Koike M, Mashino M, Sugasawa J, Koike A. Dynamic Change of histone H2AX phosphorylation independent Ngig of ATM and DNA-PK in the skin of M Mice in situ. Biochem Biophys Res Commun 2007; 363:1009 012 . 29th Kwong LN, Weiss KR, Haigis KM, Dove WF. ATM is a negative regulator of intestinal neoplasia. Oncogene. 30. 2007 Liao MJ, Dr. T. Van Dyke Critics of ATM in the suppression of VJ recombination-based thymic lymphoma. Genes & Dev 1999; 13:1246 250th 31st Liao MJ, Yin C, Barlow C, Wynshaw-Boris A, Van Dyke T. Atm is not essential for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction St. Mol Cell Biol 1999;. 19:3095 102