Moreover, there are no guidelines which recommend evaluating all these patients investigated in this Hippo pathway inhibitor research. Remarkably, after multivariable analysis, patients sustaining a minor fracture had a similar risk to a subsequent fracture as patients with a major fracture at selleck chemicals llc baseline even after a hip fracture. In addition, the same was true between sexes: After correcting for age, subsequent fracture rate was similar between men and women, as found by Center et al. [6]. Even patients with
a wrist fracture at baseline had an AR of a subsequent fracture of 17.9% within 5 years of follow-up. From a clinical point of view, these results indicate that fracture prevention should be considered after any fracture. Increasing age was the most important factor for a subsequent fracture corrected for sex and baseline fracture location. Only three variables (age, gender and fracture location) were available, and not surprisingly, age was the most predictive factor, as in
most other fracture prediction models. Over one third (36.4%) of the patients sustained a subsequent NVF within the first year after their baseline fracture. Previous studies reported similar findings. In our own previous study, we found an absolute risk of 10.8% for sustaining any clinical subsequent fracture within 2 years after baseline fracture, with 60% occurring in the first year after the baseline fracture [8]. Van Geel et al. [3] found a RR of 5.3 of subsequent fracture compared with patients without a subsequent fracture. Similar results were reported after MK-8776 cost vertebral fractures [19]. Center et al. showed that 41% of the women and 52% of the men sustained their subsequent fracture within the first 2 years after the initial fracture. The aim of this study was not to compare subsequent fracture incidence with first fracture incidence, as we already have shown in a population-based Pyruvate dehydrogenase study in post-menopausal women between ages 45 and 90 years from the same region that the 1-year incidence of all first fractures
was 1.0%. We recalculated the risk of only a first NVF which was 0.9% (excluding all patients with vertebral fractures). In that study, the first year subsequent fracture incidence was 6.0 %, almost equal as in our study (6.8%) [3]. During the study, almost one in three patients died. Our results confirm previous findings by others that mortality is associated with increasing age, male gender and baseline fracture location in a multivariable model even at the age of 50 years and over [15, 18, 20–27]. There are some potential limitations to this study. First, due to the retrospective design of this study, we could have missed subsequent fractures which had occurred outside the recruitment region of the hospital.