Intra-abdominal adhesions are strands or membranes of fibrous tissue that can be attached to the various intraabdominal organs, gluing them strongly together. Abdominal adhesions, which can begin forming within a few hours after an operation, represent the most common cause of intestinal obstruction

being responsible for 60% to 70% of SBO [1, 2]. Complications of adhesions include chronic pelvic pain (20-50% incidence), small bowel obstruction (49-74% incidence), intestinal obstruction in ovarian cancer patients (22% incidence), and infertility due to complications in the fallopian tube, ovary, and uterus (15-20% incidence) [3, 4]. Pelvic adhesions were found to be responsible in 15% to 40% of infertilities [5, 6]. Intraabdominal adhesions related BKM120 research buy to prior abdominal surgery is the etiologic factor in up to 75% of cases of small-bowel obstruction. More than 300,000 patients learn more are estimated to undergo surgery to treat adhesion-induced small-bowel obstruction in the United States annually. In details adhesiolysis was responsible for 303,836 hospitalizations during 1994, primarily

for procedures on the digestive and female reproductive systems and these procedures accounted for 846,415 days of inpatient care and $1.3 billion in hospitalization and surgeon expenditures [7]. Foster et al. reported in 2005 that during the year 1997 in the state of California, SBO accounted for 32,583 unscheduled admissions, and approximately 85% were secondary to adhesions [8]. Abdominal adhesions pose a significant health problem with major adverse effects on quality of life, use of health care resources, and financial costs. Incidence rates for abdominal adhesions have been estimated to be as high as 94% [9] -95% [10] after laparotomies. The presence of adhesions makes re-operation more difficult, adds an average Chlormezanone of 24 minutes to the surgery, increases

the risk of iatrogenic bowel injury, and makes future laparoscopic surgery more difficult or even not possible [11, 12]. Background of KU-57788 Bologna Guidelines Adhesive small bowel obstruction require appropriate management with a proper diagnostic and therapeutic pathway. Indication and length of Non Operative treatment and appropriate timing for surgery may represent an insidious issue. Delay in surgical treatment may cause a substantial increase of morbidity and mortality. However repeated laparotomy and adhesiolysis may worsen the process of adhesion formation and their severity. Furthermore the introduction and widespread of laparoscopy has raised the question of selection of appropriate patients with ASBO good candidate for laparoscopic approach. On the other hand, several adjuncts for improving the success rate of NOM and clarifying indications and timing for surgery are currently available, such as hyperosmolar water soluble contrast medium.