Indeed, we seek to explore the evidence that encompasses all the three essential atherosclerosis-related factors, namely time/ duration of atherosclerosis progression, plaque volume, and plaque vulnerability, in one study. We searched MEDLINE (1970-2013) using the subsequent keywords: “atherosclerosis progression”; “vulnerable plaque”; “risk factors”; “ plaque volume”; “atherosclerosis regression”; and “atherosclerosis Inhibitors,research,lifescience,medical duration/ time”. Searches were not limited by language or study format. We found a total of 147 studies. Moreover, we screened the reference lists of the identified articles to find additional relevant publications.

Overall, we considered 6 studies to be relevant to this review and summarized them (figure 1). Inhibitors,research,lifescience,medical Figure 1 The flow chart shows the method of MEDLINE search in our article The following is a description of our new terminology and discussion of some related topics. Phases of Atherosclerosis

and Related Factors Several previous investigations have proposed different phases for atherosclerosis progression.10,11 We believe that atherogenesis can pragmatically be divided into two phases. The first phase covers the duration from the start of lipid deposition to subsequent plaque formation, and it may lead to stable and/or unstable plaques. This may be termed the “infrastructural” phase of atherosclerosis. In this period, the plaque may be visible or invisible (subacute) Inhibitors,research,lifescience,medical in angiography. However, new methods of imaging are capable of detecting

the presence of early plaques. This first phase always happens in atherosclerosis. The second phase is frequently an acute phase, covering the duration from the point at which the plaque starts to rupture to thrombus formation, Inhibitors,research,lifescience,medical and it may give rise to acute coronary syndrome (ACS). This may be termed the “rupture-induced occlusion” phase. The second phase does not always happen in atherosclerotic patients, and subsequent ischemic events occur only because of gradual arterial narrowing in these patients Inhibitors,research,lifescience,medical (figure 2). A common finding in clinics is that the electrocardiogram (ECG) in patients with coronary artery disease, but with no previous history of myocardial infarction (MI) and also no detectable sign of MI in the ECG, shows only ischemic patterns such as T inversion or ST depression: this is a reflection of long-term ischemia without any acute infarction. After the first phase, minor ruptures and crotamiton subsequent repair and also regression might occur. Nevertheless, the occurrence of a Tacedinaline in vivo clinically relevant acute event is what constitutes the second phase. This classification is a general one that comprises all previous data regarding several phases for atherosclerosis. Furthermore, this classification is easier to use in a clinical context. Figure 2 (Atherosclerosis Velocity). This figure presents the description and application of atherosclerosis velocity.