In this paper, we present singular value decomposition (SVD) as the data-adaptive ‘sparsity’ basis, which can sparsify a broader range of MR images and perform effective image reconstruction. The performance of this method was evaluated for MR images with varying content (for example, brain images, angiograms, etc), in terms of image quality, reconstruction time, sparsity and data fidelity. Comparison with other commonly used sparsifying transforms shows that the proposed method can significantly accelerate the reconstruction process and still achieve better image quality,

providing a simple and effective alternative solution in the CS-MRI Rabusertib mouse framework.”
“A new algorithm is presented for the automatic segmentation of Multiple Sclerosis (MS) lesions in 3D Magnetic Resonance (MR) images. It builds on a discriminative random decision forest framework to provide a voxel-wise

probabilistic classification of the volume. The method uses multi-channel MR intensities (TI, 12, and FLAIR), knowledge on tissue classes and long-range spatial context to discriminate lesions from background. A symmetry feature is introduced accounting for the fact that some MS high throughput screening assay lesions tend to develop in an asymmetric way. Quantitative evaluation of the proposed methods is carried out on publicly available labeled cases from the MICCAI MS Lesion Segmentation Challenge 2008 dataset. When tested on the

same data, the presented method compares favorably to all earlier methods. In an a posteriori analysis, we show how selected features during classification can be ranked according to their discriminative power and reveal the most important ones. (C) 2011 Elsevier Inc. All rights reserved.”
“Background. An inhibitory effect Of D-allose, a rare sugar, on several cancer cell lines has been reported. This study aimed to investigate the growth inhibition of head and neck squamous cell carcinoma cells by D-allose.\n\nMethods. We treated 3 head and neck carcinoma cell lines with D-allose, D-fructose, D-psicose, and D-glucose. Cell growth GSK461364 mw assays as well as analyses of messenger RNA (mRNA) expression, cell cycle, apoptosis, and uptake of (14)C-glucose were performed.\n\nResults. D-allose had inhibitory effects on all 3 cell lines and tended to upregulate mRNA expression of glucose transporters, p21 and p53, and downregulate mRNA expression of cyclin A2, cyclin B1, and CDC2. We observed that D-allose tended to interfere with the intracellular uptake of D-glucose and induced apoptosis.\n\nConclusion. Our results indicate that D-allose inhibits the growth of head and neck squamous cell carcinoma cells. D-allose has a considerable potential as a new anticancer agent in those patients. (C) 2009 Wiley Periodicals. Inc.