Ategy. In accordance therefore, produces a HDAC inhibition Besch Ending of the frontal cortex or exposure chronicPCP acquisition deficits on a transitional object retrieval / detour task. In this study, the main effect of treatment group on the machine Bar for success was no statistical significance of 3.9, p 0.06 and there was no interaction with treatment time 0.9, p 0, 47 In the first week after the last dose of PCP, the PCP-treated patients completed fewer studies in various as their counterparts with saline Treated solution. There was no difference between groups at time points sp Tere evaluation. Number of omissions were not modulated by chronic treatment at any time, suggesting that both groups were equally motivated S in order to accomplish the task. 3.2. Effects of asenapine on the behavior of the PCP model has a number of animals U have daily doses of asenapine again, is not a complete or more sessions of reversal learning in a whole analysiswas about unm Possible because of missing cells. Since most animals at least a reversal learning assessment of each completed week averaged the dependent Ngigen variables for the two training sessions per week for each subject. With this strategy, we had a few animals with empty cells. For this reason, relate the results of analysis of variance with the other F Chern, For the data of each conversation Present ch. Because the errors were looking for the inversion and reversal criteria Ma Took modulated by chronic treatment with PCP, primary analyzes Rdaten this Ma Took concentrated. Search for errors in the inversion, as ANOVA with treatment group. Between subjects factor and week as a factor within subjects showed a main effect of group 8.3, p 0.0001 and a significant interaction arm was 1.9 weeks, p 0.03 was post-hoc Tukey HSD test, the group with untreated chronic PCP asenapine differed distinguished from all other groups, none of the other groups from one another in the search for errors reversal. For tests in total reversal of the criteria once again showed a main effect of group ANOVA therapy 3,0, p 0.02 and a significant interaction of group 2.3 weeks, p 0.007. Tukey HSD not identify reliably SSIGE group differences for the dependent Independent Variable. Our exploratory analyzes focused on the m Possible differences in the performance group at the end of treatment, 4 weeks. As shown in Fig. 3, the monkeys are PCP, which were not treated with asenapine controlled more errors than the search of repentance is exposed to saline Sung alone Them. Treatment with Asenapine 150 mg / kg after chronic PCP completely YOUR BIDDING reversed this deficit. The lowest dose produced intermediate effects, dependent Ngig dose of reactive Conductivity modulation of reversal learning. For completeness, Civil Engineering’s sake, we also investigated the error acquisition research and clinical trials to criterion of taking over this period. Neither Ma exception A main effect of group or group interaction showed week. The effect of asenapine on the site of DSB has not been studied, such as PCP-induced adversely caning this task was evident only for one week after PCP treatment. 3.3. Effects of asenapine on the neurochemistry contr down significantly in the untreated animals with PCP, chronic treatment with two t Possible Bay 43-9006 B-Raf inhibitor asenapine h Ago DA and 5HT turnover in a number of cortical regions and subcortical brain were no significant changes Changes in other brain regions examined found. 3.4. Neurochemical effects.