For the PT antigen, the percentages of subjects with at least a 4-fold increase in titre were comparable in all groups (83–89%). For the FHA antigen, the percentages were highest in the group receiving Tdap after MenACWY-CRM (90%), and lowest Erlotinib mouse in the group receiving Tdap concomitantly with MenACWY-CRM and HPV (67%). Similarly,

the percentages observed for the PRN antigen were also highest in the group receiving Tdap after MenACWY-CRM (95%) and lower in the groups receiving Tdap concomitantly with MenACWY-CRM and HPV (86%), or Tdap alone (89%). Over 98% of subjects were seronegative at baseline for HPV Types 6, 11, 16, and 18. One month after the third dose, seroconversion rates were ≥99% for all four HPV types in all groups (Table 4). The immune response to HPV given concomitantly with MenACWY-CRM and Tdap was non-inferior to the immune response of HPV given alone for all four HPV types, as measured by the percentages of subjects with anti-HPV seroconversion at 1 month after the third dose (Table

4). Geometric mean titres after HPV was given concomitantly with MenACWY-CRM and Tdap were non-inferior to those of HPV given alone for all four HPV types (Table 4). Higher post-vaccination HPV GMTs were observed among males than in females, both when HPV was given concomitantly and when given alone (data not shown). Higher post-vaccination HPV GMTs were also recorded in the younger subjects (11–14 years of age) compared with the older age strata (15–18 years of age). buy RG7204 Local reactogenicity was measured at each of the three vaccine administration sites and the results are presented for each site. Pain was the most frequent solicited local reaction for all three vaccines. Frequency

of pain was similar for MenACWY-CRM and HPV, which both had frequency and severity rates lower than for Tdap (Table 5). Frequency of pain at the MenACWY-CRM site was not modified by concomitant administration with the other vaccines; 45% when administered alone before Tdap, 48% when given alone 1 month after Tdap, Ribonucleotide reductase and 49% when administered concomitantly with Tdap and HPV (Table 5). No clinically relevant differences in the percentages of subjects reporting severe pain were observed between the three vaccine groups (Table 5). All cases of severe injection site pain (≤3%) were transient and resolved by the third day post-vaccination. Rates of other local reactions to MenACWY-CRM, erythema (MenACWY-CRM + Tdap + HPV, 13%; MenACWY-CRM → Tdap → HPV, 12%; Tdap → MenACWY-CRM → HPV, 13%), or induration (13% for all groups) were similar in the three vaccine groups (Table 5). Injection site pain after Tdap was common in each group; reported by 71% when administered alone before MenACWY-CRM, 61% when given 1 month after MenACWY-CRM, and 68% when administered concomitantly with MenACWY-CRM and HPV (Table 5).