e., a single letter is mapped onto a single word or morpheme) and therefore markedly differs orthographically from Japanese Kana. Methods Participants Ten native Chinese speakers (seven males and three Gefitinib mouse females; mean age, 25.4 years) and seven native Korean speakers (three males and four females; mean age, 26.1 years) who learned Japanese as a L2 participated in this study. No significant differences in age

were detected between the two groups of learners (ANOVA [analysis of variance]: P > 0.1). Because the age of acquisition (AOA) of words is critical in cortical representation (Wartenburger Inhibitors,research,lifescience,medical et al. 2003; Bloch et al. 2009), we controlled for the AOA between the Chinese (mean, 24.8) and Korean (mean, 22.7) learners (ANOVA: P > 0.1). The period of L2 learning did not differ between the Chinese (mean, 1.4 years; SD, 1.8) and Korean (mean, 3.4 years; SD, 4.3) learners (ANOVA: P > 0.1).

All participants were either attending university or had graduated from university Inhibitors,research,lifescience,medical and were right-handed, as assessed with the Edinburgh Handedness Inventory (Oldfield 1971). None of the participants displayed any signs or had a previous history of medical or neurological diseases. Written informed consent was obtained from each subject in accordance with the guidelines approved by Tohoku University and the Helsinki Declaration of Human Rights, 1975. This study was approved by Inhibitors,research,lifescience,medical the ethical committee of Tohoku University Medical School. The

vocabulary proficiency levels of the two learner groups were assessed with part of the level-2 Inhibitors,research,lifescience,medical Japanese language proficiency test (only the vocabulary section), which was created by Japan Educational Exchanges and Services (Tokyo, Japan). No significant differences in test scores Inhibitors,research,lifescience,medical were detected between Chinese and Korean learners (mean scores [standard deviation SD]: Chinese learners, 58.1 [12.6]; Korean learners, 53.7 [21.3], ANOVA: P > 0.1). Experimental stimuli As several studies have reported that different types of words show different Dichloromethane dehalogenase brain activation patterns during reading (Yokoyama et al. 2006b), we included both nouns and verbs in this experimental study in order to exclude the possibility that the observed effects were specific to a certain word type. The stimuli were completely identical to those used in a previous study (Yokoyama et al. 2009). The Japanese writing system uses both phonographic Kana and logographic Kanji scripts. As the majority of Kanji characters are similar to those used in Chinese, we exclusively used Kana for the representation of Japanese stimuli in order to avoid the potential use of L1 Chinese knowledge by Chinese learners. The stimuli consisted of 60 actual words and 30 pseudowords. The pseudowords were constructed by exchanging a single consonant among actual words, and all were pronounceable.