CONCLUSIONS: Results of our experiments showed that Bacillus megaterium was able to produce P(3HB) at one of the highest production rates so far reported for this bacterium, making this microorganism very interesting for industrial applications. Comparisons of shaker and bench-scale bioreactor experiments show both the importance of pH and aeration strategies. It is likely that complex aeration strategies linked to cell metabolism will be necessary for further developments using this bacterium. (C) 2009 Society of Chemical Industry”
“Purpose of reviewThe

purpose of this review is to highlight some of the advances in the way we think about rhabdomyosarcoma (RMS). Recent outcome and biological analyses have shifted the risk stratification and HDAC inhibitor treatment paradigms for pediatric RMS.Recent findingsThe presence or absence of the FOXO1 translocation is one of the most important prognostic factors in RMS. Future clinical studies will incorporate FOXO1 translocation status within risk stratification criteria. Molecular analyses have identified

RAS/NF1, hedgehog, IL-4R, and ALK pathway abnormalities as potential therapeutic targets in RMS. Reductions in systemic therapy are possible, although radiation therapy remains essential to prevent local failures in most patients.SummaryAlthough survival for RMS has not improved MLN4924 in vivo in recent years, refinement in risk stratification, further understanding of the biological drivers of the disease, and modifications in treatment intensity have set the stage for the next generation of studies in RMS.”
“BACKGROUD: Direct oxidation of alkylaromatics to the corresponding aromatic ketone is an important process in the manufacture of perfumes, pharmaceuticals, flavors, dyes and agrochemicals. For example,

tetralin is oxidized to produce 1-tetralinone, which is a key intermediate in the commercial production of 1-naphthol, 2-hydroxy-1-tetralone, aureolic acid antibiotics and other pharmaceuticals.

RESULTS: In this investigation, it was found that alkylaromatics could be efficiently and selectively oxidized to the Buparlisib clinical trial corresponding aromatic ketones when methyl violet was employed as a promotor in the presence of N-hydroxyphthalimide (NHPI); tetralin was oxidized with 89% conversion and 76% selectivity to 1-tetralinone under 0.3 MPa Of O(2) at 75 degrees C for 2.5 h. The effects of temperature, oxygen pressure, reaction time and additive inclusion were studied in detail. A possible reaction mechanism for tetralin oxidation has been proposed.

CONCLUSION: It was demonstrated that methyl violet could efficiently promote the aerobic oxidation of alkylaromatics in the presence of NHPI under mild conditions. Further investigations indicated that the nitrogen cation had a crucial promotion effect in the oxidation process.