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“Background:
Parathyroid hormone (PTH) has been shown to increase bone mineral density and to reduce the rate of fractures in patients with osteoporosis and also to improve fracture-healing. The purpose of the present prospective, randomized, controlled study was to evaluate the effect of PTH 1-84 on the course of pelvic fracture-healing and functional outcome in postmenopausal women.
Methods: Sixty-five patients had a dual x-ray absorptiometry scan, radiographs, and a computed tomography Selleck HM781-36B scan to document pelvic fractures. Twenty-one patients received a once-daily injection of 100 mu g of PTH 1-84 starting within two days after admission to the hospital, and forty-four patients served as the control group. All patients received 1000 mg of calcium and 800 IU of vitamin D. Computed tomography scans were repeated every fourth week until radiographic evidence of cortical bridging at the fracture site was confirmed. Functional outcome was assessed with use of a visual analog scale for pain and a Timed “”Up and Go”" test.
Results: The mean time to fracture
healing was 7.8 weeks for the treatment group, compared with 12.6 weeks for the control group (p < 0.001). At eight weeks, all fractures in the treatment group were healed and four fractures in the control group were healed (healing rate, 100% compared with 9.1%; p < 0.001). Both the visual analog scale score for pain and the result of the Timed “”Up and Go”" test improved in the study group as compared buy Sapitinib with the control group (p < 0.001).
Conclusions: In elderly patients with osteoporosis, PTH 1-84 accelerates fracture-healing in pelvic fractures and improves functional outcome. Level of Evidence: Therapeutic
Level II. See Instructions to Authors for a complete description of levels of evidence.”
“Ultrahigh pressure and strain-rate (pressure 10 GPa and strain rate 10(5) s(-1)) are now attainable using high-power laser systems. A laser
pulse drives a shock through a reservoir Luminespib nmr material which then unloads onto the target specimen. Laser velocimetry measurements at the back surface of the specimen are used to infer the material response. Material strength experiments have been proposed in which the pressure wave reverberates within the specimen and the cumulative resistance to compression by material strength is measured from the recorded velocimetry signature. In this work, ultrahigh pressure and strain-rate reverberation experiments are performed in tantalum, aluminum, and copper to investigate the yield strength behavior in this extreme regime. The experimental results indicate that the measurement sensitivity to yield strength is dominated by the lateral wave effects or impeded by the occurrence of spall.