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JW carried out the Anlotinib nmr experimental studies, participated in the literature research and drafted the manuscript. JBM participated in the experimental studies. GS participated in the sequence alignment, the design of the study and performed the data analysis. JM conceived of the study, and participated Hormones inhibitor in its design and helped to draft the manuscript. All authors read and approved the final manuscript.”
“Introduction Carotid body tumours (CBTs) are rare neck tumours typically located at the carotid bifurcation. They are uncommon non chromaffin paragangliomas (PGs) and contain GNA12 somatostatin receptor sites which enable localization by somatostatin receptor scintigraphy (SRS) with Indium-111-DTPA-pentetretide (Octreoscan®) using both planar and single photon emission tomography (SPECT) techniques; this modality allows to identify both the

primary tumour, bilaterality, metastases in distant locations and recurrence which is reported in about 6% of cases [1] after surgery. The main signs and symptoms of CBT include a slow growing pulsating mass at the level of carotid bifurcation and a peripheral cervical neuropathy related to the largest tumours but they may be clinically silent for a long time even when malignant. The CBT is generally benign but also the benign forms have no true capsule and grow progressively, adhering to and encasing the vessels and nerves, compressing and dislocating the pharynx and even eroding the base of the skull; therefore they should never be left untreated even when they are supposed to be benign. In addition to the potential for adjacent tissue infiltration, they can be bilateral in up to 5% of cases [2].