BALB/c mice sensitized find more and challenged to ovalbumin (OVA) were administered intragastrically with chrysin at a dose of 50 mg/kg daily. Chrysin significantly suppressed OVA-induced airway hyperresponsiveness (AHR) to acetylcholine chloride (Ach). Chrysin administration significantly inhibited the total inflammatory cell and eosinophil counts in bronchoalveolar lavage fluid (BALF) and total immunoglobulin E (IgE) levels in serum. Histological examination of lung tissue demonstrated that chrysin significantly attenuated allergen-induced lung eosinophilic inflammation
and mucus-producing goblet cells in the airway. In addition, chrysin triggered a switch of the immune response to allergens towards a T-helper
type 1 (Thl) profile by modulating the transcription factors T-bet and GATA-3 in allergic mice. These data suggest that chrysin exhibits anti-inflammatory and immunoregulatory properties and provides new insights into the immunopharmacological role of chrysin in terms of its effects in a murine model of asthma.”
“Objective: To investigate the expression of soluble vascular endothelial growth factor receptor-1 (sFlt-1) and placental growth factor (PLGF) in the fetal growth restriction (FGR) cases and the intervention (mechanism of tetramethylpyrazine. GS-9973 order Methods: A total of 60 fetal growth restriction cases that admitted to our hospital were randomly divided into ligustrazine intervention group (group A) and nutritional support group (group B). A total of 50 healthy pregnant women were also enrolled as control group (group C). Expression level of maternal serum sFlt1, PLGF and fetal growth parameters including HC, AC, FL, BPD, EFW as well as placenta PLGF, sFlt-1 mRNA expression were recorded and compared among the three groups. A total of 15 SD rats were selected and were divided into
three groups, TMP group. alcohol and tobacco group and blank control group. Three groups of rats were dissected on the twentieth day of gestation. Result: Expression level of sFlt-1 and PLGF in group A was not significantly www.selleckchem.com/products/mcc950-sodium-salt.html different from that of group C (P bigger than 0.05); but significant difference in SFlt1 and PLGF expression level was observed between group C and group B (P smaller than 0.05). Before treatment, HC, AC, FL, BPD and EFW of group A and group B were significant lower than those of group C, hut after treatment, those parameters in group A were significantly improved (P smaller than 0.05). In the animal experiment there was no significant difference in sFlt-1 between treatment group and FGR group without treatment or control group (P bigger than 0.05). There was significant difference in PLGF between FGR group with treatment and FGR group without treatment or control group (P smaller than 0.01).