At least 20% of all cancers arise in association with infection and chronic inflammation. Inflammation and cancer are linked both along intrinsic (driven by genetic events causing malignancy)
and extrinsic (driven by inflammatory conditions predisposing to tumor) pathways. Proteinases are key contributors to the breakdown and reconstitution of extracellular matrix components in physiological processes and pathological conditions, including destructive diseases and tumor progression. Matrix metalloproteinases are especially essential in the complex process of coregulation between cellular components of the tumor environment, and they are considered as potential diagnostic and prognostic biomarkers in many types and stages of cancer.
Although the link between chronic inflammation, proteinases and risk of developing cancer is now well established, several open questions remain. The most exciting challenge is to find the best approach to target cancer-associated see more inflammation in patients with cancer. With respect to matrix metalloproteinases, the development of a new generation of selective inhibitors is a promising area of research. Copyright (C) 2012 S. Karger AG, Basel”
“In this paper, nanosphere lithography (NSL) is applied to the surface of the Si3N4 trap layer in the charge trap flash device to improve its memory characteristics. A 500-nm-diameter polystyrene bead array was used as a mask to make patterns on the surface of the Si3N4 trap layer during etching processes using CF4 gases. The pattern depth measured by atomic force microscope was about 4 nm. The metal-aluminum oxide-nitride-oxide-silicon capacitor that has a patterned surface shows a larger SB202190 in vitro capacitance-voltage memory window of 5 V, higher tunneling current at bias voltages higher than 10 V. and faster program speeds of 50 ms, as compared to those measured from the capacitor with the flat
surface. These results are thought to be due to abundant memory traps available at the interface between the nitride and top oxide formed by NSL. (C) 2012 AG-014699 cell line Elsevier B.V. All rights reserved.”
“The field of orthopedics has become increasingly important at present as the number of patients diagnosed with osteoporosis increases every year. Conventional identification methods are still being used to find a suitable implant for the patient. Therefore, a digital method need to be for an effective identification of implant size, identification prosess can be effectively implemented. This paper describes the design of hip joint implant for use in digital environment. Manual implant template used by Universiti Kebangsaan Malaysia Medical Center (UKMMC) was used as the basis for the hip joint implant design. The template was redesigned using AutoCAD 2008 software. Template generated in AutoCAD format was converted to JPEG format so that it can be used in Photoshop software for colouring and scaling. The digital implant was then tested by using x-ray images of patients from by UKMMC.