Analysis for C23H26N6OS2 (466.62); calculated: C, 59.20; H, 5.62; N, 18.01; S, 13.74; found: C, 59.35; H, 5.63; N, 17.95; S, 13.70. IR (KBr), ν (cm−1): 3208 (NH), 3109 (CH Crizotinib chemical structure aromatic), 2987, 1424, 753 (CH aliphatic), 1699 (C=O), 1595 (C=N), 1519 (C–N), 1331 (C=S), 689 (C–S). 1H NMR (DMSO-d 6) δ (ppm): 1.01–1.72 (m,

10H, 5CH2 cyclohexane), 3.87 (s, 2H, CH2), 4.31 (m, 1H, CH cyclohexane), 7.28–7.56 (m, 10H, 10ArH), 8.71, 9.35, 10.20 (3brs, 3H, 3NH). 4-Phenyl-1-[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl thiosemicarbazide (4d) Yield: 91.0 %. Temperature of reaction: 50 °C https://www.selleckchem.com/products/sb273005.html for 15 h, mp: 178–180 °C (dec.). Analysis for C23H20N6OS2 (460.57); calculated: C, 59.98; H, 4.38; N, 18.25; S, 13.92; found: C, 60.03; H, 4.38; N, 18.30; S, 13.96. see more IR (KBr), ν (cm−1): 3205 (NH), 3114 (CH aromatic), 2978 (CH aliphatic), 1705 (C=O), 1610 (C=N), 1516 (C–N), 1337 (C=S), 685 (C–S). 1H NMR (DMSO-d 6) δ (ppm): 4.00 (s, 2H, CH2), 7.12–7.51 (m, 15H, 15ArH), 9.38, 9.76, 10.47 (3brs, 3H, 3NH). 13C NMR δ (ppm): 34.55 (–S–CH2–), 125.23, 125.79, 126.45, 127.77, 127.92, 128.09, 128.75, 130.07, 130.15 (15CH aromatic), 130.36, 133.78, 139.09 (3C aromatic), 151.75 (C–S), 154.48 (C-3 triazole),

166.95 (C=O), 180.98 (C=S). MS m/z (%): 460 (M+, 1), 383 (1.2), 325 (13), 294 (20), 252 (60), 194 (10), 180 (10), 149 (8), 135 (74), 131 (5), 104 (25), 91 (33), 77 (100). 4-(4-Bromophenyl)-1-[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl thiosemicarbazide (4e) Yield: 88.3 %. Temperature of reaction: 110 °C for 16 h, mp: 188–190 °C (dec.). Analysis for C23H19BrN6OS2 (539.47); calculated: C, 51.21; H, 3.55; N, 15.58; S, 11.88; Br, 14.81; found: C, 51.27; H, 3.54; N, 15.61; S, 11.92. IR (KBr), ν (cm−1): 3213

Decitabine (NH), 3116 (CH aromatic), 2972 (CH aliphatic), 1703 (C=O), 1600 (C=N), 1341 (C=S), 690 (C–S). 1H NMR (DMSO-d 6) δ (ppm): 3.97 (s, 2H, CH2), 7.29–7.55 (m, 14H, 14ArH), 9.79, 9.82, 10.46 (3brs, 3H, 3NH). 4-(4-Chlorophenyl)-1-[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl thiosemicarbazide (4f) Yield: 97.8 %.Temperature of reaction: 100 °C for 16 h, mp: 180–184 °C (dec.). Analysis for C23H19ClN6OS2 (495.02); calculated: C, 55.80; H, 3.87; N, 16.98; S, 12.95; Cl, 9.16; found: C, 55.83; H, 3.88; N, 16.93; S, 12.90. IR (KBr), ν (cm−1): 3202 (NH), 3093 (CH aromatic), 2983 (CH aliphatic), 1705 (C=O), 1608 (C=N), 1338 (C=S), 688 (C–S). 1H NMR (DMSO-d 6) δ (ppm): 3.98 (s, 2H, CH2), 7.31–7.56 (m, 14H, 14ArH), 9.81, 9.88, 10.46 (3brs, 3H, 3NH).