2003; Tamietto and de Gelder 2010; de Gelder et al. 2011). Hence, face stimuli that contain HSF information (i.e., BSF and HSF conditions) capitalize on cortical processing and hence demonstrate a differential reliance on feedforward (BSF) and reentrant (HSF) processes when suppressed with TMS. LSF face stimuli, on the other hand, rely to a much greater extent on subcortical than cortical processes. Therefore, although there were some general effects of TMS on LSF processing in both the forward and backward components, there was no overall difference between forward

and backward TMS masking. Finally, it is possible that intact BSF faces have an inherent perceptual advantage and hence benefit from faster temporal processing. Indeed, Inhibitors,research,lifescience,medical as described above, Vuilleumier et al. (2003) have demonstrated dissociation between fast subcortical LSF emotional processing and cortically mediated perception of HSF facial information. In line with this view, subcortical Inhibitors,research,lifescience,medical regions, such as the amygdala and ventral striatum, could provide the necessary (but not sufficient) coarse emotional LSF information that is being complemented Inhibitors,research,lifescience,medical by the fine-grained HSF information subserved by the fusiform cortex. In this manner, a quick and efficient perceptual processing of facial emotion information is afforded only when the broad band

of spatial frequencies is intact. Acknowledgments This study was supported by NIH R21 grant MH082303 and the NARSAD Young Investigator Award. For generous support the authors thank the Brain Mapping Medical Research Organization, Brain Mapping Support Foundation, Pierson-Lovelace Foundation, The Ahmanson Foundation, William M. and Linda R. Dietel

Philanthropic Fund at the Northern Piedmont Community Foundation, Tamkin Foundation, Jennifer Jones-Simon Inhibitors,research,lifescience,medical Foundation, Capital Group Companies Charitable Foundation, Robson Family and Northstar Fund. The project described was supported by Grant Numbers RR12169, RR13642 and RR00865 from the National Center for Research Resources (NCRR), a component of the National Institutes Inhibitors,research,lifescience,medical of Health (NIH); Bay 11-7085 its contents are solely the responsibility of the authors and do not necessarily represent the official views of NCR or NIH. The authors also thank Choi NU7441 mouse Deblieck and Ari Kappel for assistance with TMS hotspot method development. Conflict of Interest None declared.
The key role of dopaminergic drugs in modulating cognitive functions of patients with Parkinson’s disease (PD) has been consistently demonstrated (Brooks 2006; Cools 2006; Kehagia et al. 2010). In particular, dopamine replacement therapy (i.e., l-Dopa) has been shown to enhance working memory, a cognitive process depending on prefrontal cortex (PFC) and striatal circuits (Lewis et al. 2005; Cools 2006). However, dopaminergic drugs may also have detrimental effects on different neuropsychological functions such as reversal learning (Swainson et al. 2000).