Treatment and Outcome-All horses were refractory to conservative management consisting of intrabursal injection of anti-inflammatory medications. Bursoscopic see more debridement and lavage of the affected bursae resulted
in resolution of the clinical signs in all horses, and they all returned to their intended use.
Clinical Relevance-Cranial and caudal nuchal bursitis, of nonseptic or septic origin, should be considered as a differential diagnosis in horses with head and neck pain. Horses undergoing surgical intervention consisting of nuchal bursoscopy have the opportunity to return to their original degree of exercise. (J Am Vet Med Assoc 2010;237:823-829)”
“Until now there has been no information available on drug interaction between paliperidone and TS-1 (R),
an oral anticancer drug containing a 5-fluorouracil derivative. The patient in the case presented here was a 39-year-old man with a 15-year history of schizophrenia. The patient’s usual treatment of 2 mg/day of risperidone was changed to 3 mg/day of paliperidone extended release. He experienced worsening psychotic symptoms after switching from risperidone to paliperidone while he was also receiving TS-1. Retrospective analyses showed plasma concentration of paliperidone was consistently lower during the treatment with TS-1 than without TS-1. This case suggests there is drug interaction between paliperidone extended-release RAD001 tablets and TS-1.”
“Case Description-5 aged (>= 17 years old) horses developed life-threatening internal hemorrhage following IV administration of phenylephrine at
3 hospitals.
Clinical Findings-All 5 horses developed severe hemothorax, hemoabdomen, or both within minutes to hours following administration of phenylephrine.
Treatment and Outcome-Four of 5 horses died of hemorrhagic shock, and 1 horse survived with a blood transfusion. The exact source of hemorrhage was identified in only 1 horse. Medical records of all horses with nephrosplenic entrapment of the large colon and treated with phenylephrine at the University of Florida Veterinary Medical Center between 2000 and 2008 (n = 74) were reviewed. Three of these PHA-848125 concentration 74 (4%) horses developed fatal hemorrhage (horses 1 through 3 of this report). The risk of developing phenylephrine-associated hemorrhage was 64 times as high (95% confidence interval, 3.7 to 1,116) in horses >= 15 years old than in horses < 15 years old.
Clinical Relevance-The potential risks versus benefits of phenylephrine administration should be evaluated carefully, especially in old horses. (J Am Vet Med Assoc 2010;237:830-834)”
“Poorly differentiated thyroid carcinomas are a rare form of thyroid carcinomas; they display an intermediate behavior between well-differentiated and anaplastic thyroid carcinomas. PDTCs are more aggressive than the well-differentiated, but less aggressive than the undifferentiated or anaplastic, forms. No clinical features can accurately diagnose poorly differentiated thyroid carcinomas.