All doctors with these Gefitinib supplier symptoms were observed in the respondents’ group after more than 5 years work. In addition, while nasal and ocular allergy-like symptoms without work-relatedness were frequently observed among all types of allergy-like symptoms in our study; these work-related types were not as frequent as the work-related dermal type. Since environmental pollen allergy and common rhinitis are usually seen in Japan, these may overlap the doctors’ work-related nasal and ocular allergy-like symptoms. Or, as reported about occupational

allergies developing after 2–3 years of exposure to laboratory animals (Gautrin et al. 2001), the short follow-up period in our study could not have fully disclosed the prevalence of these allergy-like symptoms. Secondly, we found significant positive

associations between any types of allergy-like symptoms (respiratory, dermal, nasal, and ocular symptoms) LY2157299 manufacturer at follow-up and the baseline and follow-up questionnaire items. After adjustment, any types of allergy-like symptoms were significantly related to female gender. Additionally, after adjustment for potential confounders, a significant association was found between family history of atopic diseases (BA, AR/PA, or AD) at baseline study and allergy-like symptoms. Thirdly, we found several significant positive and inverse associations between any types of work-related allergy-like symptoms (respiratory, dermal, nasal, and ocular symptoms) and the baseline and follow-up questionnaire items. After adjustment,

work-related allergy-like symptoms were significantly related to personal history of atopic diseases (BA, AR/PA, or AD) at baseline study. This strongly suggests that atopy is a concrete predictor of work-related allergy-like symptoms. In addition, the significant association between CAP positivity for mites and Japanese cedar and work-related allergy-like symptoms supports this finding. We found that the history of eczema caused by rubber gloves, metallic accessories, e.g. earrings and wrist watches, and cosmetics, such as shampoos, soaps, hairdressings, and so on, in the baseline cAMP study lead to work-related allergy-like symptoms. Our subjects of baseline study were 4th grade medical students, and they had already been exposed to surgical gloves allergen and a variety of chemical substances during the experiments of medical school classes and the practice of human anatomy, besides allergens in daily use goods. In Japan, it was legally enacted in 1999 to provide the information about risks of latex allergy for users through the accompanying documents of medical materials. Before 1999, a great deal of latex gloves circulated on the market. It seems that part of our study population started to use latex gloves from their junior high school or high school days. About two-thirds of follow-up respondents have already worked as medical doctors on 1999 and have been exposed to latex in the work place.