“
“Hydrogels composed of etherificated sodium alginate (ESA), sodium acrylic acid (NaAA), and poly (vinyl alcohol) (PVA) were synthesized by aqueous solution polymerization. The effects of reaction variables such as terminal pH, ions, and ionic strength on hydrogel swelling ratio (SR) were determined and compared. SR was influenced strongly GANT61 nmr by pH and ionic strength. SR increased with increasing pH but tended to decrease with PVA content. At a given ionic strength, SR of ESA/NaAA/PVA
hydrogel was dependent on the valence of anion; SR was higher in multivalent anion salt solution than in monovalent anion salt solution, i.e., SR(K2SO4) > SR(KCl) and SR(Na2SO4) > SR(NaCl). The swelling kinetic of the hydrogels showed Fickian kinetic diffusion in acidic media and non-Fickian behavior in alkaline media. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 115: 3161-3167, 2010″
“Hypertension is
the most important single modifiable risk factor of stroke. The purpose of this study was to investigate the distribution patterns of risk factors of stroke and 10-year probability of stroke in hypertensive patients visiting community-based hospitals. A total of 1088 hypertensive patients who visited 61 community-based hospitals nationwide were enrolled. Risk factors of stroke were evaluated using a series of laboratory tests and physical examinations, and the 10-year probability of stroke was determined by applying the Framingham stroke risk equation. Ulixertinib solubility dmso The proportion of patients who have uncontrolled hypertension despite the use of antihypertensives was 63.3% (59.6% women, 68.7% men; P = 0.006). The average 10-year probability of stroke in hypertensive patients was 16.05% (14.68% women, 17.99% men; P < 0.001). The 10-year probability of stroke in patients with hypertension gradually increased in proportion to age. In patients treated with antihypertensives, 10-year probability of stroke gradually increased in proportion to blood pressure. The 10-year risk of stroke in hypertensive patients was approximately 4.6 GM6001 supplier times higher than that of stroke in the general population. In conclusion, as the 10-year risk of stroke in hypertensive
patients was approximately 4.6 times higher than that of stroke in the general population, more aggressive interventions are needed to reduce blood pressure and stroke risk in hypertensive patients.”
“Liposomes incorporating sodium deoxycholate (NaDC) were prepared by the method of reverse phase evaporation and used for drug delivery by the oral route. Hexamethylmelamine (HMM), an anti-tumor agent, was chosen as a model drug and encapsulated into liposomes incorporating NaDC (NaDC-Lip). Several properties of NaDC-Lip containing HMM (HMM NaDC-Lip), such as particle size, entrapment efficiency, pinacyanol chloride (PIN) spectral characteristics with various molar ratio of NaDC/PC, as well as the vesicle stability measurements with calcein were evaluated.