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“Disease modeling with human pluripotent stem cells has come into the public spotlight with the awarding of the Nobel Prize in Physiology or Medicine for 2012 to Drs John Gurdon and Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent. This discovery has opened the door for the generation of pluripotent stem cells from individuals with disease and the differentiation of these cells into somatic cell types for the study of disease pathophysiology. The emergence of genome-editing technology over the past few years has made it feasible to generate and investigate human cellular disease models with even greater speed and efficiency. Here,

recent technological advances in genome editing, and its utility in human biology and disease studies, are reviewed.”
“The present work reports the development of aqueous gelcasting of ZTA ceramic with a low-toxicity monomer DMAA. The rheological properties and the gelation behaviors EVP4593 order of the slurries for gelcasting were investigated. It was proved that the time available for casting the slurry (idle time) can be controlled by the amounts of initiator. The ZTA green bodies exhibited a mechanical strength as high as 21 MPa. After sintered at 1600 degrees C for 2 h, the highest bending strength and fracture toughness of the sintered ZTA samples were as high as 643.3 +/- 75 MPa and 6.3 +/- 0.3 MPa m(1/2),

respectively. SEM photographs revealed that the green bodies and sintered part GDC-0994 had a uniform microstructure. The volume fraction of tetragonal phase zirconia was as high as 90%. Dense ZTA P5091 green bodies and ceramic parts with complex shaped were

produced through the new gelcasting system. (C) 2011 Elsevier Ltd and Techna Group S.r.l. All rights reserved.”
“Sexual dysfunction is a common problem for women and often impairs their quality of life. Many women are reluctant to discuss these issues with their physicians. The perimenopause presents unique changes in sexual function. At this time, women and their partners undergo numerous physiologic, psychologic, and social/cultural changes. Women should be encouraged to engage their physicians in discussions to help them maintain a satisfying sexual life during this time of change.\n\nTarget Audience: Obstetricians & Gynecologists, Family Physicians\n\nLearning Objectives: After completion of this article, the reader will be able to describe the types of female sexual disorders, summarize a plan of treatment for the different female sexual disorders, and outline special conditions during the perimenopause which might affect sexual function.”
“This paper exploits the inherent cyclic and periodic free-spectral-range (FSR) properties of arrayed-waveguide grating (AWG) routers to construct a two-dimensional (2D) time-spreading and wavelength-group-hopping embedded M-sequence code for optical multiple-access networks. In the proposed codecs (encoder/decoder), a.